He is D. Jaime and Joana de Mendonça’s fourth son. As a young man he was called by the King John III to be the King’s Chamberlain.
 In 1557, when the King died, Sir Constantino lost his job. But it was necessary to nominate a new governor to the Indian colony and he offers himself to the job, to the regents of the kingdom, with D. Teodósio’s help. Even though he’s not experience, in 1558, he’s nominated Governor of India. The story of his government as Vice-king was glorious.
 Sir Constantino arrived in Goa in 3 September 1558, and he immediately managed to get the King of Cambaia’s submission to the Portuguese Crown, in turn it would give him protection against his enemies.
 In the 2nd of February 1559, the 7th Vice-king of India, captures Daman. After this success he draws the attention of the Indian State to Jafanapatan, whose kingdom was enemy of the Portuguese and, in 1560, the city is captured. However, due to the city natives’ resistance it was later abandoned.
 To the annals of history remains the episode with an Indian shrine the Portuguese drew from a pagoda and took to Goa, delivering it to D. Constantino. It was one of Buda’s teeth. In 1561, some of the King of Pegu’s ambassadors went to Goa to redeem the relic offering a large amount of money. The Archbishop Sir Gaspar helped by the opinion of a theological council which met specially for the occasion, convinced Sir Constantino not to accept the deal, supposedly much profitable to the pecuniary resources of the Indian State, delivering it instead to the Archbishop who destroyed it as to put an end to the superstitious and devilish idolatry derived from the gentiles worship. The Jesuits applauded the Vice-king’s decision whilst the ambassadors got terribly disappointed.
 In 1561, the Earl of Redondo D. Francisco Godinho arrives in Goa, to succeed D. Constantino, who returns to Lisbon, as Vice-King.
 After his arrival in the kingdom he was given the Cape Verde Captaincy, which he rented to take shelter in Estremoz with his wife. He spent his old age in Vila Viçosa. He died in the 14th of July 1575 and was buried in the Church of Chagas.
 He was a very religious man, friend of justice, true and pure, gentle and kind. Neither did he get rich in India, nor did he use his job in his own profit, which caused some strangeness in the metropolis.